Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central structures involved in opioid-induced feeding.

B A Gosnell

    Federation Proceedings
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    This study identifies brain structures regulating feeding behavior via opioids. Research indicates the hypothalamus, including specific nuclei, plays a key role in the central opioid feeding system.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism.

    International journal of obesity (2005)·2010
    Same author

    Reward systems and food intake: role of opioids.

    International journal of obesity (2005)·2009
    Same author

    Modulation of long-term potentiation in the rat hippocampus following cocaine self-administration.

    Neuroscience·2004
    Same author

    Food presentation and energy intake in a feeding laboratory study of subjects with binge eating disorder.

    The International journal of eating disorders·2001
    Same author

    Long-term follow-up of patients' status after gastric bypass.

    Obesity surgery·2001
    Same author

    Sucrose intake predicts rate of acquisition of cocaine self-administration.

    Psychopharmacology·2000

    Area of Science:

    • Neuroscience
    • Neurobiology of Feeding Behavior

    Background:

    • Opioid agonists and antagonists centrally administered affect food intake, suggesting a brain-based opioid feeding system.
    • Changes in opioid peptide levels in brain regions like the hypothalamus correlate with hunger and feeding states.

    Purpose of the Study:

    • To identify specific brain structures involved in the central opioid regulation of feeding behavior.
    • To consolidate evidence from various experimental approaches to map the opioid feeding system.

    Main Methods:

    • Review of studies involving central injections of opioid agonists and antagonists.
    • Analysis of changes in opioid peptide levels during feeding and hunger.
    • Examination of lesion studies affecting opioid-induced feeding responses.
    • Microinjection mapping of brain areas for opioid feeding effects.

    Related Experiment Videos

    Main Results:

    • Evidence suggests the opioid feeding system is primarily located within the brain.
    • The hypothalamus, particularly the paraventricular nucleus, ventromedial nucleus, and lateral hypothalamic area, is implicated.
    • Lesion and microinjection studies consistently point to these hypothalamic regions as critical components.

    Conclusions:

    • Multiple lines of evidence converge to identify key hypothalamic structures in the opioid regulation of feeding.
    • The paraventricular nucleus, ventromedial nucleus, and lateral hypothalamic area are crucial nodes in this neural circuitry.