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Neural cell adhesion molecule expression in Xenopus embryos.

K Balak, M Jacobson, J Sunshine

    Developmental Biology
    |February 1, 1987
    PubMed
    Summary
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    Neural cell adhesion molecule (NCAM) expression in Xenopus embryos marks key developmental stages, including neural tube formation and nerve fiber tract development. This study maps NCAM

    Area of Science:

    • Developmental biology
    • Neuroscience
    • Cell adhesion molecules

    Background:

    • Neural cell adhesion molecule (NCAM) is crucial for nervous system development.
    • Understanding NCAM's spatiotemporal expression is key to deciphering neural morphogenesis.

    Purpose of the Study:

    • To map the expression pattern of NCAM during early Xenopus development.
    • To correlate NCAM expression with specific developmental events like neural tube formation and neurite outgrowth.

    Main Methods:

    • Immunohistochemistry using a polyclonal antibody against Xenopus NCAM.
    • Analysis of NCAM expression from blastula to early swimming stages in Xenopus embryos.

    Main Results:

    • NCAM expression begins at the neural plate stage.

    Related Experiment Videos

  • NCAM is detected in neural ectoderm, mesoderm, and chordamesodermal tissues.
  • Expression is observed in neural crest cells, developing nerve fiber tracts, and neuromuscular junctions.

    • Conclusions:

    • NCAM is expressed post-neural induction and plays a role in neural plate and tube morphogenesis.
    • NCAM is involved in the development of neural crest derivatives and peripheral nervous system connections.
    • The study highlights NCAM's function in forming central and peripheral nerve pathways and neuromuscular junctions.