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Elderly-onset generalized pustular psoriasis: a case series.

Jen-Ping Chao¹, Tsen-Fang Tsai^1,2

¹Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.

Clinical and Experimental Dermatology

|April 15, 2022

Summary

Elderly-onset generalized pustular psoriasis (GPP) is rare and presents uniquely. This study found a lower frequency of IL36RN mutations in these patients, suggesting a dose-dependent effect on GPP onset age.

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Published on: September 20, 2018

Area of Science:

Dermatology
Genetics
Immunology

Background:

Elderly-onset atopic dermatitis and psoriasis exhibit distinct clinical features.
Generalized pustular psoriasis (GPP) typically begins in middle age, with elderly onset being exceptionally rare.
Research on elderly-onset GPP is limited due to its infrequent occurrence.

Observation:

A case series of seven patients with GPP onset after age 60 was analyzed.
Clinical characteristics of these elderly GPP patients were documented.
Genetic analysis focused on the c.115+6T>C mutation in the IL36RN gene.

Findings:

Patients with elderly-onset GPP displayed atypical clinical presentations.
The IL36RN c.115+6T>C mutation was found less frequently in this cohort.
IL36RN mutations appear to influence the age of GPP onset in a dose-dependent manner.

Implications:

Understanding GPP pathogenesis in older adults requires further investigation.
The role of IL36RN in GPP onset timing warrants deeper study.
These findings contribute to characterizing rare GPP phenotypes in the elderly population.