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[Advances in research of Musashi2 in solid tumors]

Y Yang1,2, M Zhao3,1, T Ding1

  • 1Clinical Innovation and Research Center, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|April 15, 2022
PubMed

Insights

Musashi-2 (Msi2) is a key RNA-binding protein implicated in stem cell regulation and tumor development. This review details Msi2

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • RNA-binding proteins (RBPs) are crucial regulators of gene expression, influencing mRNA translation, modification, splicing, and transport.
  • Aberrant RBP expression is linked to various diseases, highlighting their significance in cellular function.
  • The Musashi (Msi) family, including Msi1 and Msi2, are conserved RBPs vital for stem cell activity and tumor development.

Purpose of the Study:

  • To review the molecular structure and physiological functions of Musashi-2 (Msi2).
  • To elucidate the role of Msi2 in the development and progression of solid tumors.
  • To summarize the signaling pathways influenced by Msi2 in tumorigenesis.

Main Methods:

  • Literature review of preclinical and clinical studies on Msi2.
  • Analysis of Msi2's involvement in key cellular processes like proliferation, invasion, and metastasis.
  • Examination of Msi2's interaction with major signaling pathways (e.g., Wnt/β-catenin, TGF-β/SMAD3, Akt/mTOR, JAK/STAT).

Main Results:

  • Msi2 is critical for embryonic development, stem cell maintenance, and hematological tumor progression.
  • Msi2 significantly impacts solid tumor development by affecting proliferation, invasion, metastasis, and drug resistance.
  • Msi2 regulates tumor progression through modulation of pathways including Wnt/β-catenin, TGF-β/SMAD3, Akt/mTOR, and JAK/STAT.

Conclusions:

  • Msi2 is a significant factor in the development and progression of various solid tumors.
  • Targeting Msi2 presents a promising therapeutic strategy for cancer treatment, with preliminary preclinical success.
  • Understanding Msi2's role in signaling pathways is crucial for developing effective anti-cancer therapies.
Keywords:
Musashi2RNA-binding proteinsmall molecular inhibitorsolid tumor

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