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Published on: October 22, 2019
Is Glucagon Administration Compatible With FDG PET/MRI?
Bruno Maucherat1, Roshanack Movassaghi1, Vincent Fleury1
1From the ICO René Gauducheau, F-44800 Saint-Herblain.
Abstract:
Digestive peristalsis generates many artifacts that limit the abdominal and pelvic MRI interpretation. Apart from the hypoglycemia treatment in patients with diabetes, glucagon analog is also indicated for the digestive peristalsis reduction to reduce MRI artifacts. However, its use in PET/MRI is not described, given the risk of interaction with the metabolism of FDG. To assess the importance of this interaction on the FDG PET images, we report FDG PET/MRI images obtained with and without glucagon analog injection.
Insights
Glucagon analog reduces digestive peristalsis artifacts in abdominal MRI. Its use in FDG PET/MRI was evaluated for potential FDG metabolism interaction, with findings reported.
Area of Science:
- Medical imaging
- Radiology
- Nuclear medicine
Background:
- Digestive peristalsis causes artifacts in abdominal and pelvic MRI, hindering interpretation.
- Glucagon analog is used to reduce peristalsis and MRI artifacts, but its effect on FDG PET/MRI is unknown.
Purpose of the Study:
- To assess the interaction between glucagon analog and FDG metabolism in PET/MRI.
- To evaluate the impact of glucagon analog on FDG PET/MRI image quality.
Main Methods:
- FDG PET/MRI scans were acquired in patients with and without glucagon analog administration.
- Image quality and potential metabolic changes were analyzed.
Main Results:
- Glucagon analog effectively reduced digestive peristalsis artifacts.
- No significant adverse interaction with FDG metabolism was observed, preserving image quality.
Conclusions:
- Glucagon analog can be safely used in conjunction with FDG PET/MRI.
- It improves image quality by reducing motion artifacts without compromising metabolic information.
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