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Altered glucagon release in biotin deficiency
General and Comparative Endocrinology
|January 1, 1987
Summary
Biotin deficiency in chickens does not impair insulin or glucagon release. This suggests biotin-dependent enzymes are not crucial for hormone regulation during fasting or challenges.
Area of Science:
- Animal Nutrition
- Biochemistry
- Endocrinology
Background:
- Biotin deficiency impairs liver enzymes and gluconeogenesis in chickens.
- The impact of biotin deficiency on fasting glucose regulation and hormonal responses is unclear.
Purpose of the Study:
- To determine if biotin deficiency affects insulin and glucagon release.
- To assess the role of these hormones in maintaining fasting glucose levels and responding to challenges.
Main Methods:
- Chicks were fed biotin-deficient or supplemented diets for 9 weeks.
- Fasting, intravenous glucose, and protein challenges were administered.
- Plasma glucose, insulin, and glucagon levels were measured.
Main Results:
- Basal glucose and suppressed insulin levels were similar between groups after fasting.
- Glucagon levels were elevated in biotin-deficient birds post-fasting.
- Insulin response to glucose and glucagon response to protein were not impaired by biotin deficiency.
Conclusions:
- Biotin deficiency does not impair the release of insulin or glucagon.
- Hormonal regulation of glucose appears intact despite impaired gluconeogenesis.