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Alzheimer's: The ABCDE Paradigm
Mayuri Gupta1, Donald F Weaver1,2
1Krembil Research Institute, University Health Network, 60 Leonard Avenue, Toronto M5T 0S8, Canada.
Abstract:
Alzheimer's disease (AD) and related dementias constitute a worldwide health crisis for which the design and development of global solutions is a neuropharmacologic priority. The much-publicized failures of multiple investigational agents for AD over the past 20 years drive the need to rethink our approach to therapeutics development. Herein we present the ABCDE paradigm as a conceptual tool to facilitate the development of safe, effective therapies for AD cure: (A) accessible; (B) blood-brain barrier permeant; (C) cognitive enhancing; (D) disease-modifying; (E) environmentally nontoxic.
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