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Updated: Sep 27, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
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A Nanopore Based Molnupiravir Sensor.

Wendong Jia1,2, Chengzhen Hu1,2, Yuqin Wang1,2

  • 1State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, 210023, Nanjing, China.

ACS Sensors
|April 15, 2022
PubMed
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A new nanopore sensor can detect the antiviral drug molnupiravir and its metabolites. This rapid detection method, using machine learning, achieved 92% accuracy for SARS-CoV-2 research.

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Drug Discovery

Background:

  • Nucleoside analogues are crucial in antiviral and anticancer therapies.
  • Molnupiravir, a nucleoside analogue, demonstrates efficacy against SARS-CoV-2.
  • Direct molecular sensing of molnupiravir and its metabolites is currently lacking.

Purpose of the Study:

  • To develop a direct sensing method for molnupiravir and its primary metabolites.
  • To enable rapid pharmacological evaluation of molnupiravir.
  • To establish a versatile sensing platform for nucleoside analogue drugs.

Main Methods:

  • Development of a novel nanopore-based sensor.
  • Simultaneous detection of molnupiravir, β-d-N4-hydroxycytidine, and its triphosphate.
Keywords:
Mycobacterium smegmatis porin Amolnupiravirnucleoside analoguesprogrammable nanoreactorssingle-molecule chemistry

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  • Application of a custom machine learning algorithm for data analysis.

    • Main Results:

    • Successful direct sensing of molnupiravir and its two major metabolites.
    • Achieved 92% accuracy in distinguishing and quantifying the analytes.
    • Demonstrated the potential for simultaneous detection.

    Conclusions:

    • The developed nanopore sensor provides a rapid and accurate method for detecting molnupiravir and its metabolites.
    • This sensing strategy is valuable for evaluating drug pharmacology during pandemics.
    • The platform is adaptable for sensing other nucleoside analogue drugs.