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Updated: Sep 26, 2025
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Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
Published on: June 17, 2013
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Parkinsonism in multiple sclerosis patients: A prospective observational study
Shlok Sarin1, Alexander Wang2, Mohamed Elkasaby2
1Case Westerns Reserve University School of Medicine, Cleveland, OH, USA.
Multiple Sclerosis and Related Disorders
|April 15, 2022
Summary
Parkinsonism is rare in multiple sclerosis (MS) patients, often being incidental. However, demyelination-related parkinsonism can occur, potentially being the sole presentation of progressive MS.
Area of Science:
- Neuroimmunology
- Movement Disorders
- Neurology
Background:
- Coexistence of multiple sclerosis (MS) and parkinsonism is rarely reported.
- Systematic evaluation of prevalence, clinical features, and causality is lacking.
Purpose of the Study:
- To determine the prevalence of parkinsonism in MS patients.
- To investigate the potential causal link between MS and parkinsonism.
Main Methods:
- Neurological evaluation of MS patients by specialists in neuroimmunology and movement disorders.
- Screening for movement disorders using surveys and focused examinations.
- Independent blinded rating of video samples for parkinsonism phenomenology.
Main Results:
- 12 out of 336 MS patients (3.6%) exhibited parkinsonism.
- Most cases were incidental (idiopathic Parkinson's disease or drug-induced).
- One case of demyelination-related chronic symptomatic parkinsonism was identified, presenting solely with parkinsonism.
Conclusions:
- Parkinsonism in MS is uncommon, usually incidental.
- Demyelination-related parkinsonism should be recognized in progressive MS with basal ganglia lesions.
- Parkinsonism can be the sole presenting symptom of MS, guiding treatment decisions.
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