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Published on: April 1, 2019
CYP3a5 Genetic Polymorphism in Chinese Population With Renal Transplantation: A Meta-Analysis Review
Peng Cao1, Feilong Zhang1, Jiandong Zhang1
1Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Background:
Tacrolimus is a common immunosuppressive for transplantation. The enzyme encoded by the CYP3A5 gene can regulate the metabolism of tacrolimus, and the polymorphism of the CYP3A5 gene regulates the enzyme function. However, its characteristics in Chinese kidney transplant recipients remain unclear.
Methods:
A computer-based database retrieval included Pubmed, Web of Science, Embase, China National Knowledge Infrastructure, China Biology Medicine Disc, and WanFang databases between January 2010 and December 2020. Search terms included "CYP3A5," "polymorphism," and "renal transplantation." Literature included in this study had sample sizes >130. Genetic testing data of CYP3A5*1/*1, *1/*3, *3/*3 genes were analyzed using a statistical method of meta-analysis to explore the mutation rate of CYP3A5 in Chinese and foreign populations.
Results:
The frequency of the A allele in the CYP3A5 gene was 23% in all transplant recipients from the 28 included studies. The frequency in Chinese renal transplant recipients was 29%, and it was 30% in renal transplant recipients from other Asian countries but significantly higher than that in Western renal transplant recipients (14%). In subgroup analysis, the frequencies of the A allele in renal transplant recipients in different parts of China were comparable.
Conclusions:
We found that there were significant differences in CYP3A5 gene polymorphism between Asians and Westerners. There was no significant difference in the frequency of the A allele in CYP3A5 gene among Chinese renal transplant recipients from different parts of China.
Insights
The CYP3A5 gene polymorphism significantly impacts tacrolimus metabolism in kidney transplant recipients. Frequencies of the A allele differ between Asian and Western populations, with comparable rates across different regions in China.
Area of Science:
- Pharmacogenomics
- Transplantation immunology
- Genetic epidemiology
Background:
- Tacrolimus is a crucial immunosuppressant in organ transplantation.
- The CYP3A5 gene influences tacrolimus metabolism through its encoded enzyme.
- CYP3A5 gene polymorphism's role in Chinese kidney transplant recipients requires clarification.
Purpose of the Study:
- To investigate the characteristics of CYP3A5 gene polymorphism in Chinese kidney transplant recipients.
- To compare the frequency of CYP3A5 gene variants between Chinese and other populations.
- To analyze the mutation rate of CYP3A5 in global populations.
Main Methods:
- Comprehensive literature search of multiple databases (PubMed, Embase, CNKI, etc.) from 2010-2020.
- Inclusion criteria: studies with sample sizes >130 on CYP3A5 polymorphism and renal transplantation.
- Meta-analysis of genetic testing data (CYP3A5*1/*1, *1/*3, *3/*3) to determine allele frequencies.
Main Results:
- The overall A allele frequency in CYP3A5 was 23% across 28 studies.
- Chinese renal transplant recipients showed a 29% A allele frequency, higher than Western recipients (14%).
- Asian populations exhibited a 30% A allele frequency, with comparable rates among different regions in China.
Conclusions:
- Significant disparities in CYP3A5 gene polymorphism exist between Asian and Western populations.
- No significant regional variations in A allele frequency were observed among Chinese kidney transplant recipients.
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