Lipids and diastolic dysfunction: Recent evidence and findings.
Padideh Daneii1, Sina Neshat1, Monir Sadat Mirnasiry1
1School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|April 16, 2022
Summary
Lipid metabolism significantly impacts left ventricular diastolic dysfunction, a key factor in heart failure. Understanding cardiac lipid profiles and metabolism is crucial for developing effective treatments for this condition.
Area of Science:
- Cardiology
- Metabolic Disorders
- Molecular Biology
Background:
- Diastolic dysfunction, characterized by impaired left ventricular relaxation, is a major contributor to heart failure.
- Lipid metabolism is increasingly recognized for its role in cardiovascular health, including cardiac function.
- Existing research highlights connections between lipid profiles and various cardiac conditions.
Purpose of the Study:
- To review existing literature on the relationship between lipids, their storage, and metabolism in the context of left ventricular diastolic dysfunction.
- To synthesize current knowledge on how alterations in lipid metabolism affect myocardial function.
- To explore the implications of lipid profiles in the pathogenesis of diastolic dysfunction.
Main Methods:
- Comprehensive literature search across major scientific databases including Google Scholar, PubMed, Embase, and ResearchGate.
- Keywords used for the search were 'Diastolic function', 'Fat', and 'Lipid profile'.
- Initial screening of 250 articles by title, followed by a detailed review of 84 highly relevant studies.
Main Results:
- Alterations in cardiac lipid metabolism and content are associated with conditions like high-fat diets, obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD).
- These metabolic changes lead to increased myocardial fat, epicardial fat thickness, inflammation, oxidative stress, and ultimately cardiac lipotoxicity, contributing to diastolic dysfunction.
- The impact of lipids on diastolic function may vary based on gender.
Conclusions:
- Lipid profile and metabolism are critical factors in the pathogenesis of diastolic dysfunction, similar to their role in other cardiovascular diseases.
- Further in-depth investigation into cardiac lipid metabolism at molecular, histological, and gross levels is needed for a precise understanding of its role in myocardial function.
- A detailed understanding may pave the way for novel therapeutic strategies targeting lipid metabolism for diastolic dysfunction.
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