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C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies

Xintao Li1, Shi Peng1, Xiaoyu Wu1

  • 1Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|April 16, 2022
PubMed

Insights

Elevated C-reactive protein (CRP) is linked to atrial fibrillation (AF) in observational studies. However, genetic analysis did not confirm a causal role for CRP in AF development.

Area of Science:

  • Cardiology
  • Epidemiology
  • Genetics

Background:

  • C-reactive protein (CRP) is an inflammatory marker.
  • Atrial fibrillation (AF) is a common cardiac arrhythmia.
  • The relationship between CRP and AF requires further investigation.

Purpose of the Study:

  • To investigate the association between C-reactive protein (CRP) and atrial fibrillation (AF).
  • To examine the epidemiological and genetic links between CRP and AF.
  • To assess the causal role of CRP in AF development.

Main Methods:

  • Utilized data from the Kailuan cohort (n=86,424) with baseline and follow-up CRP measurements and ECG assessments.
  • Employed Cox proportional hazards models to analyze CRP levels and AF risk.
  • Conducted a meta-analysis of nine cohort studies and performed Mendelian randomization (MR) analysis.

Main Results:

  • High baseline CRP was not significantly associated with AF risk.
  • High cumulative CRP exposure showed a significant association with increased AF risk (HR: 1.49).
  • Meta-analysis indicated a positive association between elevated CRP and incident AF (RR: 1.27), but MR analysis found no genetic link.

Conclusions:

  • Observational data suggest a positive association between elevated CRP and incident AF.
  • Mendelian randomization analysis did not support a causal effect of CRP on AF.
  • The etiological role of CRP in AF remains uncertain.
Abstract

Keywords:
Atrial fibrillationC-reactive proteinCumulative burdenMendelian randomizationRisk assessment

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