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Low-ratio somatic NLRC4 mutation causes late-onset autoinflammatory disease

Jun Wang1,2, Qiao Ye3, Wenjie Zheng4

  • 1Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China.

Annals of the Rheumatic Diseases
|April 16, 2022
PubMed
Summary

A somatic mutation in NLRC4 causes late-onset autoinflammatory disease. This study identified the mutation in monocytes and demonstrated a potential treatment targeting gasdermin D.

Keywords:
arthritisarthritis, rheumatoidimmune system diseasesinflammation

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