Related Experiment Video
Updated: Sep 26, 2025
11:17
Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
Published on: August 24, 2012
35.6K
The time window of reconsolidation: A replication
Colleen M Parks1, Kevin D Mohawk2, Laura L S Werner2
1Psychology Department, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA. colleen.parks@unlv.edu.
Psychonomic Bulletin & Review
|April 16, 2022
Summary
Memory reconsolidation is time-dependent. This study replicated findings showing memory updating occurs only when reconsolidation has sufficient time, supporting the reconsolidation theory.
Area of Science:
- Cognitive Neuroscience
- Memory Research
- Learning and Memory
Background:
- Memory reconsolidation involves updating consolidated memories after reactivation.
- A key aspect of reconsolidation theory is its time-dependent nature.
- Previous research suggests memory updating requires sufficient time for reconsolidation.
Purpose of the Study:
- To directly replicate experiments on the time-dependency of memory reconsolidation.
- To further validate the reconsolidation theory of memory updating.
- To investigate whether memory updating is contingent on the duration of the reconsolidation window.
Main Methods:
- Direct replication of Hupbach et al. (2007) experiments.
- Utilizing both 2-day and 3-day experimental paradigms.
- Assessing memory updating following memory reactivation and varying restabilization periods.
Main Results:
- Memory updating was observed in the 3-day paradigm, consistent with sufficient time for reconsolidation.
- Memory updating was not observed in the 2-day paradigm, indicating insufficient time for reconsolidation.
- Replication confirmed the time-dependent nature of memory updating during reconsolidation.
Conclusions:
- The findings strongly support the reconsolidation theory of memory updating.
- Memory updating is critically dependent on the time available for the reconsolidation process.
- The results challenge alternative explanations for memory updating mechanisms.
More Related Videos
Related Concept Videos
02:53Conservative Site-specific Recombination and Phase Variation
6.2K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
The recognition sites for Cre recombinase called LoxP...
6.2K
01:30Crossing Over
4.8K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
4.8K
01:03Long-term Depression
2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.7K