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Bridging structural and functional biomarkers in functional movement disorder using network mapping.

Petr Sojka1, Matěj Slovák2, Gabriela Věchetová2

  • 1Department of Psychiatry, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czech Republic.

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Summary

Functional movement disorder (FMD) involves multiple brain networks, particularly the temporoparietal junction. Symptom severity in FMD correlates with structural changes in specific brain regions linked to connectivity.

Keywords:
MRIfunctional connectivityfunctional movement disorderfunctional neurological disordersalience networktemporoparietal junction

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Area of Science:

  • Neuroscience
  • Neurology
  • Neuroimaging

Background:

  • Significant gaps exist in the neurobiological understanding of functional movement disorder (FMD).
  • Investigating the neurobiological underpinnings of FMD is crucial for developing targeted treatments.

Purpose of the Study:

  • To investigate gray matter volumetric profiles in FMD patients.
  • To correlate these structural findings with resting-state functional connectivity (rsFC) using Human Connectome Project data.
  • To explore the relationship between FMD symptom severity and brain structure.

Main Methods:

  • Compared gray matter volumes between 53 FMD patients and 50 controls.
  • Examined correlations between FMD symptom severity and volumetric profiles.
  • Utilized atrophy network mapping to assess the impact of structural alterations on brain areas with dense rsFC.

Main Results:

  • No significant volumetric differences were found between FMD patients and controls.
  • Individual differences in FMD symptom severity negatively correlated with volumes in the right supramarginal and bilateral superior temporal gyri.
  • Symptom severity-related structural alterations were concentrated in brain regions with dense rsFC, implicating default mode, ventral attention, and salience networks.

Conclusions:

  • Functional movement disorder (FMD) is characterized as a multinetwork disorder.
  • The temporoparietal junction and its connectivity play a significant role in FMD pathophysiology.
  • Further research is needed to understand the interplay between functional neurological symptoms and mood in FMD.