Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

391
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
391
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

176
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
176
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

230
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
230
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

149
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
149
Long-term Depression01:03

Long-term Depression

2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.7K
Stress and Mental Health01:30

Stress and Mental Health

231
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
231

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) 2025 international guidelines for the management of patients with obsessive-compulsive disorder.

Journal of psychiatric research·2026
Same author

The Theory of Metabolic Jet Lag in Bipolar Disorder: A Pilot Feasibility Study Exploring the Association Between Eating Rhythm Disruption and Illness Burden Parameters.

Bipolar disorders·2026
Same author

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report.

Bipolar disorders·2026
Same author

Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same author

The Canadian multi-ethnic research on aging (CAMERA) study: Design, participant characteristics, and preliminary findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Learning to Blink Strategically Is Crucial to Performance in a Predictable Saccade Task and Varies Across the Lifespan.

Journal of cognitive neuroscience·2026

Related Experiment Video

Updated: Sep 26, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.8K

Is subthreshold depression in adolescence clinically relevant?

Blake K Noyes1, Douglas P Munoz2, Sarosh Khalid-Khan3

  • 1Centre for Neuroscience Studies, Queen's University, Kingston, Canada.

Journal of Affective Disorders
|April 16, 2022
PubMed
Summary

Subthreshold depression is as clinically significant as major depressive disorder in adolescents, affecting them similarly and occurring twice as often. Early recognition of subthreshold depression is crucial for intervention.

Keywords:
AdolescenceMajor depressive disorderMoodSubthreshold depression

More Related Videos

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

827
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.2K

Related Experiment Videos

Last Updated: Sep 26, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.8K
Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

827
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.2K

Area of Science:

  • Adolescent psychiatry
  • Mental health research
  • Neuroscience

Background:

  • Subthreshold depression is common in adolescents but under-researched compared to major depressive disorder.
  • Understanding its clinical impact is vital for effective adolescent mental healthcare.

Purpose of the Study:

  • To compare subthreshold depression and major depressive disorder in adolescents.
  • To review epidemiology, risk factors, trajectories, neurobiology, genetics, and treatment.

Main Methods:

  • Scoping review of English-language papers on adolescent depression.
  • Included adult studies when adolescent data were unavailable.

Main Results:

  • Subthreshold depression and major depressive disorder share similarities in demographics, onset, impairment, comorbidity, healthcare use, suicidal ideation, genetics, brain changes, and treatment response.
  • Subthreshold depression is approximately twice as prevalent as major depressive disorder in adolescents.

Conclusions:

  • Subthreshold depression holds significant clinical importance, supporting a spectrum model of depressive symptoms.
  • Increased recognition and awareness can drive early prevention and intervention strategies for adolescent depression.