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Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved...

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Related Experiment Video

Updated: Sep 26, 2025

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

DNA modified MSN-films as versatile biointerfaces to study stem cell adhesion processes.

Xingzhen Zhang¹, Sabine van Rijt¹

¹Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

Colloids and Surfaces. B, Biointerfaces

|April 16, 2022

Summary

This summary is machine-generated.

Researchers developed novel biointerfaces using DNA-functionalized mesoporous silica nanoparticles (MSN) to control stem cell adhesion. These platforms promote human mesenchymal stem cell (hMSC) adhesion and spreading, offering new tools for studying cell-environment interactions.

Keywords:

Biointerface Cell adhesion DNA Ligand presentation Mesoporous silica nanoparticle Stem cell

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Published on: April 23, 2017

Area of Science:

Biomaterials Engineering
Stem Cell Biology
Nanotechnology

Background:

Clinical translation of stem cells is limited by controlling cell behavior post-transplantation.
Stem cell fate is regulated by extracellular matrix (ECM) interactions, primarily via integrin-mediated adhesion.
2D biointerfaces presenting ECM ligands aid in studying stem cell-environment interactions.

Purpose of the Study:

To develop a novel biointerface platform using mesoporous silica nanoparticles (MSN) for controlled stem cell adhesion.
To investigate the role of ECM-derived ligands, specifically RGD peptides, in regulating stem cell behavior.
To explore the influence of surface properties, such as PEG linker length, on cell adhesion and spreading.

Main Methods:

Fabrication of DNA-functionalized MSN (MSN-ssDNA) with varying polyethylene glycol (PEG) linker lengths.
Conjugation of RGD tripeptide to complementary DNA strands to form MSN-dsDNA-RGD films.
Assessment of human mesenchymal stem cell (hMSC) adhesion and morphology on developed biointerfaces.
Evaluation of the effect of PEG linker length on cell adhesion.

Main Results:

MSN-dsDNA-RGD films significantly promoted hMSC adhesion and spreading.
MSN-dsDNA films lacking RGD peptides resulted in poor cell spreading and low adhesion.
Stem cell adhesion was dependent on the length of the PEG linker used in the biointerface.
The platform demonstrated potential for incorporating multiple ECM ligands and soluble cues.

Conclusions:

DNA-functionalized MSN-based biointerfaces offer a versatile platform for engineering stem cell adhesion.
The RGD peptide presentation via DNA hybridization is effective in promoting stem cell attachment and spreading.
Surface properties, including PEG linker length, critically influence stem cell-biointerface interactions.
This novel tool facilitates the study of ligand-stem cell interactions for regenerative medicine applications.