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Cost-effectiveness of artificial intelligence for screening colonoscopy: a modelling study.

Miguel Areia¹, Yuichi Mori², Loredana Correale³

¹RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto, Porto, Portugal; Gastroenterology Department, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.

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Summary

Artificial intelligence (AI) tools enhance colonoscopy by improving precancerous polyp detection, leading to better colorectal cancer prevention. Implementing AI in screening colonoscopies is a cost-saving strategy that reduces cancer incidence and mortality.

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Area of Science:

Medical technology
Gastroenterology
Oncology

Background:

Colorectal cancer (CRC) remains a significant health concern.
Screening colonoscopy is a primary method for CRC prevention.
Artificial intelligence (AI) shows promise in enhancing polyp detection during colonoscopy.

Purpose of the Study:

To evaluate the incremental impact of AI detection tools in screening colonoscopy on CRC incidence and mortality.
To assess the cost-effectiveness of implementing AI in CRC screening programs.

Main Methods:

Markov model microsimulation of a hypothetical US cohort (100,000 individuals).
Comparison of screening colonoscopy with and without AI every 10 years (ages 50-80) and once-in-life screening at age 65.
Analysis of CRC incidence, mortality, and costs, with a 3% annual discount rate.

Main Results:

AI-assisted colonoscopy demonstrated a 4.8% incremental gain in reducing CRC incidence and a 3.6% incremental gain in reducing CRC mortality compared to standard colonoscopy.
AI tools resulted in a cost saving of $57 per screened individual, decreasing costs from $3400 to $3343.
Population-level impact projected an annual prevention of 7,194 CRC cases and 2,089 deaths, with savings of $290 million.

Conclusions:

Implementation of AI detection tools in screening colonoscopy is a cost-effective strategy.
AI significantly enhances the prevention of colorectal cancer incidence and mortality.
AI integration into screening colonoscopies offers substantial public health and economic benefits.