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DNA damage response and repair in the development and treatment of brain tumors
Parisa Maleki Dana1, Fatemeh Sadoughi1, Hamed Mirzaei1
1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Abstract:
DNA damage response (DDR) comprising DNA repair and cell-cycle checkpoint pathways, is considered as a protective process that maintains the integrity of the genome. However, this mechanism may not be favorable in the context of cancer. Indeed, studies have shown that DDR and repair mechanisms can be involved in the development of different cancers. Furthermore, they may lead to the failure of therapeutic approaches. Thus, studying these mechanisms can be beneficial in a better understanding of cancer development and developing more efficient treatments. Scopus, Google Scholar, and PubMed databases were used for searching articles published on "DNA damage response and DNA repair in the development and treatment of brain tumors". Herein, we review the literature on DNA damage response and DNA repair mechanisms in the development of brain tumors, such as glioma, glioblastoma, and medulloblastoma. Moreover, we summarize the studies that conducted on the role of targeting components of DNA damage response and DNA repair in treating different types of brain cancers, enhancing the currently available therapeutic approaches, and solving the problems in the field of brain cancer therapy.
Insights
The DNA damage response (DDR) pathway, crucial for genome integrity, can paradoxically promote cancer. Understanding DDR and DNA repair in brain tumors is key to developing more effective cancer treatments.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The DNA damage response (DDR) is a protective mechanism for genome integrity.
- However, DDR and DNA repair pathways can contribute to cancer development and treatment resistance.
- Studying these mechanisms is vital for understanding cancer and improving therapies.
Purpose of the Study:
- To review the literature on DDR and DNA repair in brain tumor development.
- To summarize the role of targeting DDR and DNA repair in treating brain cancers.
- To enhance current therapeutic strategies and address challenges in brain cancer therapy.
Main Methods:
- Literature search using Scopus, Google Scholar, and PubMed.
- Focus on articles related to "DNA damage response and DNA repair in the development and treatment of brain tumors."
- Review of studies on glioma, glioblastoma, and medulloblastoma.
Main Results:
- DDR and DNA repair mechanisms are implicated in the development of brain tumors like glioma and glioblastoma.
- Targeting DDR and DNA repair components shows potential for treating brain cancers.
- These strategies may overcome therapeutic failures and improve brain cancer treatment outcomes.
Conclusions:
- DDR and DNA repair play a dual role in cancer, both protective and potentially promoting.
- Targeting these pathways offers a promising avenue for novel brain cancer therapies.
- Further research into DDR and DNA repair is essential for advancing brain cancer treatment.
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