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Updated: Sep 26, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Collapsing glomerulopathy in a patient with mixed connective tissue disease

Mohammad Atari1, Josephine M Ambruzs2, Osaid Saqqa3

  • 1Division of Nephrology and Hypertension, School of Medicine, Tulane University, New Orleans, LA, USA.

The American Journal of the Medical Sciences
|April 17, 2022
PubMed

Insights

Collapsing glomerulopathy (CG) in mixed connective tissue disease (MCTD) is rare. Steroids and mycophenolate showed promise in one challenging case, highlighting the need for treatment guidelines.

Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Background:

  • Collapsing glomerulopathy (CG) is a severe podocytopathy with challenging management.
  • CG can be idiopathic or linked to autoimmune connective tissue diseases (ACTDs).
  • Therapeutic guidelines for CG in ACTDs are lacking.

Observation:

  • A unique case of CG with mixed connective tissue disease (MCTD) is presented.
  • The patient's CG responded to initial steroid therapy followed by mycophenolate.
  • A literature review identified three prior cases of CG with MCTD and other autoimmune diseases.

Findings:

  • CG associated with ACTDs disproportionately affects females and Black patients.
  • Treatment responses in CG associated with ACTDs are variable and often inconsistent.
  • Despite various treatments, many patients with CG in ACTDs progress to end-stage renal disease requiring dialysis.

Implications:

  • This case and review underscore the complexity of managing CG in the context of MCTD.
  • Further research is needed to establish effective therapeutic strategies for CG in ACTDs.
  • Developing clear treatment guidelines is crucial for improving outcomes in these patients.

Keywords:
AutoimmuneCollapsing glomerulopathyLupusMCTDProteinuria

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