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Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
Published on: September 20, 2016
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Cannabinoid crystal polymorphism.
1PerkinElmer Health Sciences Inc, 940 Winter Street, Waltham, MA, 02451, USA. crist.filer@perkinelmer.com.
Journal of Cannabis Research
|April 18, 2022
Summary
Cannabinoids typically exist as amorphous solids, but this commentary presents evidence suggesting they may also form distinct crystal polymorphs. This finding has implications for cannabinoid science and drug development.
Area of Science:
- Pharmaceutical Sciences
- Solid-State Chemistry
Background:
- Cannabinoids are commonly encountered as amorphous solids, lacking long-range molecular order.
- The concept of crystal polymorphism, where a compound exists in multiple crystalline forms, is well-established in pharmaceutical chemistry.
Discussion:
- This commentary explores the potential for cannabinoid crystal polymorphism, challenging the assumption of their amorphous nature.
- It reviews existing evidence and scientific precedent supporting the existence of different cannabinoid crystalline structures.
- Understanding cannabinoid solid-state forms is crucial for predicting and controlling their physical and chemical properties.
Key Insights:
- Cannabinoid crystal polymorphism is a plausible phenomenon supported by scientific evidence.
- Different polymorphic forms can exhibit distinct solubility, stability, and bioavailability.
- Recognition of cannabinoid polymorphism is essential for consistent drug formulation and manufacturing.
Outlook:
- Further research is needed to identify and characterize specific cannabinoid polymorphs.
- Investigating cannabinoid polymorphism can lead to improved therapeutic efficacy and novel drug delivery systems.
- This area of study holds significant potential for advancing cannabinoid-based medicine.
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