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Updated: Sep 26, 2025
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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Validating the Mild Behavioral Impairment Checklist in a Cognitive Clinic: Comparisons With the Neuropsychiatric
Sophie Hu1,2, Scott Patten1,2,3,4, Anna Charlton5
1Department of Community Health Sciences, 2129University of Calgary, Calgary, AB, Canada.
Journal of Geriatric Psychiatry and Neurology
|April 18, 2022
Summary
The Mild Behavioral Impairment-Checklist (MBI-C) and Neuropsychiatric Inventory Questionnaire (NPI-Q) both effectively capture neuropsychiatric symptoms (NPS) across cognitive decline stages. Higher scores on both checklists correlate with worse cognitive status and lower Montreal Cognitive Assessment (MoCA) scores.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Neuropsychiatric symptoms (NPS) are common in neurocognitive disorders.
- Accurate assessment of NPS is crucial for diagnosis and management across cognitive stages, from subjective cognitive decline (SCD) to dementia.
- The Mild Behavioral Impairment-Checklist (MBI-C) and Neuropsychiatric Inventory Questionnaire (NPI-Q) are commonly used tools for NPS assessment.
Purpose of the Study:
- To compare the clinical utility of the MBI-C and NPI-Q in identifying and characterizing NPS.
- To evaluate the performance of these checklists across different stages of cognitive impairment: subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia.
- To determine the association between NPS, cognitive status (assessed by MoCA), and demographic factors.
Main Methods:
- A cross-sectional study was conducted in a memory clinic setting.
- Linear regression models were employed to compare MBI-C (n=474) and NPI-Q (n=1040) scores against the Montreal Cognitive Assessment (MoCA) score.
- Prevalence of MBI and associations with diagnostic status, MoCA scores, and age were analyzed.
Main Results:
- MBI prevalence increased with cognitive decline severity: 37% in SCD, 54% in MCI, and 62% in dementia.
- Worse diagnostic status, lower MoCA scores, and older age were significantly associated with higher MBI-C and NPI-Q scores (P < .001).
- Both MBI-C (β -.09) and NPI-Q (β -.17) scores were inversely associated with MoCA scores, indicating greater NPS with poorer cognition. Psychosis showed the strongest association.
Conclusions:
- The MBI-C demonstrates utility in capturing both global and domain-specific NPS throughout the spectrum of cognitive decline.
- Both the MBI-C and NPI-Q are valuable tools for characterizing neuropsychiatric symptoms in individuals with cognitive impairment.
- These findings support the use of both checklists in clinical settings for comprehensive NPS assessment in memory clinics.
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