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A Timeline of Ca2+/cAMP Signalling: From Basic Research to Potential Therapeutics for Dementia

Leandro B Bergantin1

  • 1Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669, Vila Clementino, São Paulo, SP, Postal Code: 04039-032, Brazil.

Current Alzheimer Research
|April 18, 2022
PubMed
Abstract

Insights

Calcium (Ca2+) dyshomeostasis is linked to dementia. Targeting Ca2+/cAMP signaling offers a novel therapeutic strategy for dementia and related conditions like hypertension and diabetes.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cell Biology

Background:

  • Calcium (Ca2+) dyshomeostasis is increasingly recognized as a contributing factor to dementia.
  • Lifestyle factors such as exercise and cognitive engagement may mitigate Ca2+ excess.
  • A link exists between hypertension, diabetes, inflammatory processes, and cognitive decline, with Ca2+ dyshomeostasis as a potential upstream cause.

Purpose of the Study:

  • To explore the pharmacological manipulation of Ca2+/cAMP signaling as a novel therapeutic target for dementia.
  • To review current dementia therapies and novel approaches targeting Ca2+/cAMP signaling.
  • To discuss the role of Ca2+ channel blockers in COVID-19-related signaling disruptions.

Main Methods:

  • Review of fundamental concepts and current therapies for dementia.
  • Analysis of scientific literature on Ca2+/cAMP signaling and its role in neurological disorders.
  • Inclusion of recent reports on Ca2+ channel blockers and COVID-19.

Main Results:

  • Pharmacological targeting of Ca2+/cAMP signaling presents a promising avenue for dementia treatment.
  • Combined therapeutic strategies involving novel drugs and lifestyle improvements may enhance patient quality of life.
  • Ca2+ channel blockers show potential in restoring disrupted Ca2+ signaling.

Conclusions:

  • Ca2+/cAMP signaling modulation is a potential novel therapeutic strategy for dementia.
  • Integration of lifestyle changes and novel therapeutics can improve outcomes for age-related neurological conditions.
  • Understanding Ca2+/cAMP signaling dynamics is crucial for developing effective dementia treatments.
Keywords:
Alzheimer’s diseaseCOVID- 19CaCaneurodegenerative diseasesrolipram

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