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Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
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Bioactive Molecule-incorporated Polymeric Electrospun Fibers for Bone Tissue Engineering
Aarkampoondi Elumalai Purushothaman1, Ranganathan Abhinandan1, Senthilkumar Pranav Adithya1
1Department of Biotechnology, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603 203, Tamil Nadu, India.
Current Stem Cell Research & Therapy
|April 18, 2022
Summary
Electrospun fibers made from polymers and bioceramics show promise for bone tissue engineering. Loading these scaffolds with bioactive molecules enhances stem cell differentiation for bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Bone tissue engineering (BTE) aims to regenerate bone using biomaterials, cells, and bioactive molecules.
- Electrospinning fabricates fibrous scaffolds mimicking natural tissue architecture for BTE.
- Common materials include polymers (chitosan, PCL, PLA) and bioceramics (hydroxyapatite).
Approach:
- This review examines electrospun fibers for BTE applications.
- It focuses on polymer and bioceramic-based scaffolds.
- The influence of bioactive molecules on stem cell differentiation is highlighted.
Key Points:
- Electrospun scaffolds provide a nanoscale, porous structure conducive to tissue formation.
- Stem cells are crucial for BTE due to their regenerative potential.
- Bioactive molecules (drugs, growth factors, phytocompounds) guide stem cell differentiation into osteoblasts.
Conclusions:
- Electrospun fibers loaded with bioactive molecules effectively support osteogenic differentiation of stem cells.
- This approach holds significant potential for advancing bone regeneration therapies.
- Further development of these composite scaffolds is crucial for clinical translation.
