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New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology
1Universidad del Valle, Facultad de Salud, Escuela de Ciencias Básicas, Departamento de Morfología, Cali, Colombia.
Insights
Gastroschisis, a congenital abdominal wall defect, is increasingly prevalent globally. Recent research points to genetic factors and environmental influences converging in its complex pathogenesis.
Area of Science:
- Developmental biology
- Medical genetics
- Epidemiology
Background:
- Gastroschisis is a congenital defect involving abdominal viscera protrusion through an abdominal wall defect.
- Its developmental, etiological, and epidemiological aspects remain subjects of ongoing scientific debate.
- Recent evidence suggests a role for genetic/chromosomal alterations and a stress-induced pathway involving risk factors.
Purpose of the Study:
- To review current knowledge on gastroschisis.
- To consolidate information on embryonic development relevant to the defect.
- To explore theories on origin, pathogenesis, and recent epidemiological findings.
Main Methods:
- Comprehensive review of the medical literature.
- Consultation of bibliographic databases and standard search engines.
- Synthesis of information on ventral body wall, primitive intestine, and umbilical cord complex development.
Main Results:
- The review gathers data on embryonic development of key structures.
- It compiles theories regarding gastroschisis origin and pathogenesis.
- Recent epidemiological evidence on the growing global prevalence is presented.
Conclusions:
- Gastroschisis pathogenesis likely involves a multifactorial pathway.
- Understanding embryonic development is crucial for explaining the defect.
- Further research is needed to elucidate the complex etiology and epidemiology.
Abstract:
gastroschisis is a congenital structural defect of the abdominal wall, most often to the right of the umbilicus, through which the abdominal viscera protrude. Its developmental, etiological and epidemiological aspects have been a hot topic of controversy for a long time. However, recent findings suggest the involving of genetic and chromosomal alterations and the existence of a stress-inducing pathogenetic pathway, in which risk factors such as demographic and environmental ones can converge. To expand the frontier of knowledge about a malformation that has showed a growing global prevalence, we have conducted a review of the medical literature that gathers information on the embryonic development of the ventral body wall, the primitive intestine, and the ring-umbilical cord complex, as well as on the theories about its origin, pathogenesis and recent epidemiological evidence, for which we consulted bibliographic databases and standard search engines.
