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The Potential Role of Small Nucleolar RNAs in Cancers - An Evidence Map

Fanqi Wu1, Longguo Zhang2, Pingfan Wu3

  • 1Department of Respiratory, Lanzhou University Second Hospital, Lanzhou, Gansu Province, People's Republic of China.

International Journal of General Medicine
|April 18, 2022
PubMed
Abstract

Insights

Dysregulated small nucleolar RNAs (snoRNAs) impact cancer development and patient survival. This evidence map highlights their potential as diagnostic biomarkers and therapeutic targets for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer poses a significant global health burden.
  • Small nucleolar RNAs (snoRNAs) are increasingly recognized for their roles in tumorigenesis.

Purpose of the Study:

  • To systematically assess the impact of dysregulated snoRNAs on various cancers.
  • To create an evidence map visualizing the relationship between snoRNAs and cancer.

Main Methods:

  • A comprehensive literature search was conducted across four databases up to February 2022.
  • Keywords included "carcinoma", "neoplasms", "tumor", "cancer", "snoRNA", and "small nucleolar RNA".
  • Data were screened by two independent reviewers, and visualization tools (bubble plots, mind maps, heatmaps) were employed.

Main Results:

  • 102 studies were analyzed, revealing associations between dysregulated snoRNAs and cancer clinicopathological characteristics.
  • Abnormal snoRNA expression correlated with tumor cell phenotypes and poor patient survival.
  • snoRNAs demonstrated diagnostic efficiency and could modulate cancer cell processes by affecting rRNA, mRNA, and protein factors.

Conclusions:

  • Ectopic snoRNAs show promise as biomarkers for cancer clinical assessment, diagnosis, and prognostic prediction.
  • Dysregulated snoRNAs represent potential therapeutic strategies for cancer treatment.
  • This visual analysis provides valuable insights for researchers studying snoRNAs in cancer.
Keywords:
biomarkersdiagnosismalignant neoplasmsprognosissnoRNAs

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