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Simultaneous Presentation of Glioblastoma Multiforme in Divorced Spouses
Cassie M Fehr1, Roland N Auer2
1Division of Neurology, Department of Internal Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
Case Reports in Oncology
|April 18, 2022
Summary
This case study reports a rare instance of a divorced couple presenting simultaneously with glioblastoma multiforme. Molecular analysis suggests independent tumor development, highlighting endogenous factors in gliomagenesis.
Area of Science:
- Neuro-oncology
- Genetics
- Epidemiology
Background:
- High-grade gliomas are common adult brain tumors.
- Glioblastoma multiforme, though rare, presents diagnostic challenges.
- Concurrent gliomas in spouses are exceptionally uncommon.
Observation:
- A divorced couple, living apart for 20 years, presented concurrently with malignant astrocytomas.
- They recognized each other by voice in the emergency room.
- Tumor molecular characteristics were analyzed.
Findings:
- The molecular profiles favored independent development of primary glioblastomas in both individuals.
- This supports the hypothesis that gliomagenesis is an independent event in spouses.
- Endogenous factors damaging DNA are implicated in tumor development.
Implications:
- Despite rare conjugal presentations, gliomas may develop independently in spouses.
- Increasing glioma incidence may lead to more recognition of concurrent, independent tumors in couples.
- Further research into endogenous DNA damage and gliomagenesis is warranted.
