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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Choroidal Vascularity Index Changes After Exercise in Patients With Glaucoma.

Dan Cheng1, Jia Fang2, Weiqian Gao1

  • 1The Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, China.

Frontiers in Physiology
|April 18, 2022
PubMed
Summary

Glaucoma patients experienced a significant drop in choroidal vascularity index (CVI) immediately after exercise, indicating impaired vascular regulation. CVI levels recovered after a rest period, suggesting exercise impacts choroidal structures.

Keywords:
choroidal vascularity indexexerciseglaucomaoptical coherence tomographyprimary open-angle glaucoma

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Area of Science:

  • Ophthalmology
  • Cardiovascular Research

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Choroidal vascularity plays a role in ocular health and disease progression.
  • Exercise can influence physiological parameters, including intraocular pressure and vascular function.

Purpose of the Study:

  • To assess changes in choroidal vascular structures in glaucoma patients post-exercise.
  • To utilize enhanced-depth imaging optical coherence tomography and an image binarisation algorithm.
  • To investigate the choroidal vascularity index (CVI) as a marker of vascular response to exercise.

Main Methods:

  • Thirty-four eyes of 19 primary open-angle glaucoma patients and 40 eyes of 20 controls were studied.
  • Measurements were taken before, immediately after, and 30 minutes after a 20-minute moderate-speed run.
  • Subfoveal choroidal area was analyzed for luminal area (LA) and stromal area (SA) to calculate CVI (LA/TCA).

Main Results:

  • Glaucoma patients showed a significant decrease in CVI immediately post-exercise, with recovery after 30 minutes.
  • Total choroidal area (TCA) and luminal area (LA) were higher 30 minutes post-exercise compared to immediately after.
  • Intraocular pressure (IOP) decreased transiently in both groups post-exercise, returning to baseline after rest.

Conclusions:

  • Exercise acutely affects choroidal vascularity in glaucoma patients, evidenced by a reduced CVI.
  • The findings suggest a potentially compromised vascular regulatory mechanism in the choroid of glaucoma patients.
  • Further research is needed to understand the long-term implications of exercise on glaucoma progression.