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Identification of Functionally-Relevant Lentivirus Integration Sites in an Insertional Mutagenesis Cell Library
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Geminivirus-Derived Vectors as Tools for Functional Genomics.

Bipasha Bhattacharjee1,2, Vipin Hallan1,2

  • 1Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.

Frontiers in Microbiology
|April 18, 2022
PubMed
Summary

Geminiviruses cause significant crop damage globally. However, their unique characteristics make them valuable tools for plant bioengineering and functional genomics research.

Keywords:
CRISPR/Cas9biopharmaceuticalscrop improvementgeminiviruspeptide expression systemssilencing systemviral vector

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Area of Science:

  • Plant Virology
  • Molecular Biology
  • Agricultural Science

Background:

  • Geminiviruses are a major threat to global agriculture, causing extensive crop damage due to their diversity, rapid evolution, and broad host range.
  • These viruses possess small, versatile genomes (monopartite or bipartite) and can replicate independently within plant cells without integrating into the host genome.

Purpose of the Study:

  • To highlight significant characteristics of geminiviruses.
  • To review successful case studies of exploiting geminiviruses in functional biology and genomics.

Main Methods:

  • Review of existing literature on geminivirus biology and applications.
  • Analysis of geminivirus properties relevant to plant bioengineering.
  • Case study examination of geminivirus-derived tools.

Main Results:

  • Geminiviruses' ability to replicate independently and their small genome size make them suitable for plant bioengineering.
  • Geminiviruses can function as natural nanoparticles for applications like vaccine development and gene silencing.
  • Geminivirus-induced gene silencing (GIGS) and deconstructed viral vectors are effective tools.

Conclusions:

  • Geminiviruses, despite their pathogenic nature, offer significant potential as beneficial tools in functional genomics.
  • Understanding geminivirus biology is crucial for harnessing their capabilities in plant biotechnology and crop improvement.