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Interleukin-22 in Renal Protection and Its Pathological Role in Kidney Diseases
Qianqian Ma1, Jingyun Luan2,3, Yu Bai2,3
1Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Frontiers in Immunology
|April 18, 2022
Summary
Interleukin-22 (IL-22) aids kidney epithelial repair but can also harm kidneys by activating immune responses. Understanding IL-22
Area of Science:
- Nephrology
- Immunology
- Molecular Biology
Background:
- Chronic kidney injury affects 10% of the global population, often progressing to end-stage renal disease.
- Interleukin-22 (IL-22) is a cytokine crucial for epithelial homeostasis, tissue repair, and immune response.
- IL-22 signaling involves JAK/Tyrosine Kinase 2 and downstream pathways like STAT3, MAPK, and PKB.
Purpose of the Study:
- To review the structure, origin, and signaling pathways of IL-22.
- To summarize the physiological and pathological roles of IL-22 in kidney diseases.
- To explore potential therapeutic strategies involving IL-22 for kidney conditions.
Main Methods:
- Literature review of current knowledge on IL-22.
- Analysis of IL-22's role in kidney epithelial homeostasis and repair.
- Examination of IL-22's dual effects in autoimmune kidney diseases.
Main Results:
- IL-22 promotes kidney tissue repair, regeneration, and barrier integrity.
- IL-22 signaling can activate complement systems and chemokine infiltration, contributing to kidney damage.
- Dysregulation of IL-22 contributes to conditions like lupus nephritis and IgA nephropathy.
Conclusions:
- IL-22 exhibits a dual role in kidney health, promoting repair while potentially causing damage.
- Targeting IL-22 pathways may offer novel therapeutic avenues for kidney diseases.
- Further research is needed to harness IL-22's beneficial effects while mitigating its detrimental impacts.
Keywords:
basic featuresbiological effectsinterleukin-22kidney diseasesthe pathological effectthe protective roleMore Related Videos
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