Related Experiment Video
Updated: Sep 26, 2025
12:50
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
6.7K
CARD9 Signaling, Inflammation, and Diseases
Xuanyou Liu1,2, Bimei Jiang3, Hong Hao1
1Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, University of Missouri, Columbia, MO, United States.
Frontiers in Immunology
|April 18, 2022
Summary
Caspase-recruitment domain 9 (CARD9) protein is crucial for immune system function and inflammatory responses. CARD9 dysregulation is linked to various diseases, highlighting its importance in health and pathology.
Area of Science:
- Immunology
- Molecular Biology
- Cell Signaling
Background:
- Caspase-recruitment domain 9 (CARD9) is expressed in immune cells.
- CARD9 is vital for innate and adaptive immunity.
- CARD9 interacts with signaling molecules like NF-κB and MAPK.
Purpose of the Study:
- To review the function of CARD9 and its signaling pathways.
- To explore CARD9 interactions with other signaling molecules.
- To examine the role of CARD9 in various diseases.
Main Methods:
- Literature review of CARD9 function and signaling.
- Analysis of CARD9 interactions in different cell types.
- Correlation of CARD9 with pathological conditions.
Main Results:
- CARD9 signaling regulates inflammatory responses and oxidative stress.
- Cytokine and chemokine production is mediated by CARD9.
- CARD9 abnormalities are associated with infections, inflammation, and autoimmune disorders.
Conclusions:
- CARD9 plays a central role in immune cell function.
- CARD9 signaling is implicated in inflammatory diseases, infections, tumorigenesis, and cardiovascular pathologies.
- Understanding CARD9 pathways is critical for disease management.
Related Concept Videos
01:20The JAK-STAT Signaling Pathway
9.4K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.4K
01:28Inflammatory Response
9.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
9.1K
01:38Inflammation
55.6K
Overview
55.6K
01:21Paracrine Signaling
56.2K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
56.2K
01:30Inflammatory Response I: Vascular and Cellular
12.8K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
12.8K
01:24T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K