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CARD9 Signaling, Inflammation, and Diseases

Xuanyou Liu1,2, Bimei Jiang3, Hong Hao1

  • 1Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, University of Missouri, Columbia, MO, United States.

Frontiers in Immunology
|April 18, 2022
PubMed

Insights

Caspase-recruitment domain 9 (CARD9) protein is crucial for immune system function and inflammatory responses. CARD9 dysregulation is linked to various diseases, highlighting its importance in health and pathology.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Signaling

Background:

  • Caspase-recruitment domain 9 (CARD9) is expressed in immune cells.
  • CARD9 is vital for innate and adaptive immunity.
  • CARD9 interacts with signaling molecules like NF-κB and MAPK.

Purpose of the Study:

  • To review the function of CARD9 and its signaling pathways.
  • To explore CARD9 interactions with other signaling molecules.
  • To examine the role of CARD9 in various diseases.

Main Methods:

  • Literature review of CARD9 function and signaling.
  • Analysis of CARD9 interactions in different cell types.
  • Correlation of CARD9 with pathological conditions.

Main Results:

  • CARD9 signaling regulates inflammatory responses and oxidative stress.
  • Cytokine and chemokine production is mediated by CARD9.
  • CARD9 abnormalities are associated with infections, inflammation, and autoimmune disorders.

Conclusions:

  • CARD9 plays a central role in immune cell function.
  • CARD9 signaling is implicated in inflammatory diseases, infections, tumorigenesis, and cardiovascular pathologies.
  • Understanding CARD9 pathways is critical for disease management.

Keywords:
CARD9CARD9-associated diseasesautophagycardiovascular diseasescytokinesoxidative stresstumor

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