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Related Experiment Videos

Hormone production in clinically nonfunctioning pituitary adenomas.

P M Black, D W Hsu, A Klibanski

    Journal of Neurosurgery
    |February 1, 1987
    PubMed
    Summary

    Most pituitary tumors considered nonfunctioning actually contain glycoprotein hormone subunits. This finding suggests these subunits may not cause excess hormone secretion, explaining their "nonfunctioning" status.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Biology

    Background:

    • Nonfunctioning pituitary adenomas (NFAs) are clinically defined by a lack of excess hormone secretion.
    • Previous studies suggested NFAs lack specific hormone production.

    Purpose of the Study:

    • To investigate the presence of hormone subunits in clinically nonfunctioning pituitary tumors.
    • To determine the prevalence and types of hormone subunits in NFAs.

    Main Methods:

    • Immunocytochemical staining of 160 pituitary tumors from patients without clinical hormone excess.
    • Antibodies used targeted prolactin, growth hormone, ACTH, and glycoprotein hormone subunits (alpha, beta-LH, beta-FSH, beta-TSH).

    Main Results:

    • 73% of NFAs showed immunoreactivity for one or more pituitary hormones.

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  • Glycoprotein hormone alpha and beta subunits were frequently detected (68%), with beta-FSH (58%) and beta-LH (47%) being most common.
  • Co-expression of multiple glycoprotein hormone subunits occurred in 52% of cases.

    • Conclusions:

    • Apparently nonfunctioning pituitary tumors frequently express glycoprotein hormone subunits.
    • The production of subunits alone may not lead to clinically apparent endocrine syndromes.
    • This challenges the traditional definition of null-cell adenomas.