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Buerger Disease: Pathological Changes in Elderly Patients.

Takehisa Iwai1,2, Hiroko Kume1,2, Shinya Koizumi1,2

  • 1Keiyukai Tsukuba Vascular Center, Moriya, Ibaraki, Japan.

Annals of Vascular Diseases
|April 18, 2022
PubMed
Summary

Elderly Buerger disease patients over 50 with risk factors like hypertension may develop atherosclerosis. Atherosclerosis was found in the iliac or aortic regions alongside thromboangiitis lesions.

Keywords:
Buerger diseaseagingatherosclerosisatherosclerotic risk factorsthromboangiitis

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Area of Science:

  • Vascular Medicine
  • Geriatric Medicine
  • Cardiovascular Pathology

Background:

  • Buerger disease typically affects younger individuals and is characterized by inflammatory vascular lesions.
  • Vascular lesion changes in elderly Buerger disease patients, especially those with comorbidities, are infrequently reported.
  • The progression of Buerger disease in patients over 50 with atherosclerotic risk factors remains poorly understood.

Purpose of the Study:

  • To investigate the vascular lesion changes in elderly Buerger disease patients (around or after age 50) who develop atherosclerotic risk factors.
  • To describe the clinical presentation and pathological findings in these specific patient cases.
  • To elucidate the potential interplay between Buerger disease and common atherosclerotic risk factors in older adults.

Main Methods:

  • Case series reporting on three elderly patients diagnosed with Buerger disease.
  • Assessment of patients with comorbidities including hypertension, diabetes mellitus, and hyperlipidemia.
  • Evaluation of vascular lesions in the iliac and aortic regions in conjunction with thromboangiitis below the groin area.

Main Results:

  • Atherosclerosis was identified in the iliac or aortic regions of the reported patients.
  • These atherosclerotic changes coexisted with residual thromboangiitis lesions distal to the groin.
  • The findings suggest a potential shift or complication in vascular pathology in older Buerger disease patients with risk factors.

Conclusions:

  • Elderly Buerger disease patients exceeding 50 years of age and presenting with atherosclerotic risk factors may exhibit secondary atherosclerosis.
  • The coexistence of thromboangiitis and atherosclerosis in these patients indicates a complex vascular disease process.
  • Further research is warranted to understand the long-term implications and management strategies for this patient subgroup.