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Management of Type 2 Diabetes in Stage C Heart Failure with Reduced Ejection Fraction

Anjali Agarwalla1, Jadry Gruen2, Carli Peters2

  • 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania Philadelphia, PA, US.

Cardiac Failure Review
|April 18, 2022
PubMed

Insights

Type 2 diabetes and heart failure with reduced ejection fraction (HFrEF) often coexist and worsen each other. New antidiabetic drugs show heart failure benefits, requiring updated clinical guidance for managing these concurrent conditions.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Type 2 diabetes is a growing comorbidity in patients with stage C heart failure with reduced ejection fraction (HFrEF).
  • These conditions are mutually exacerbating risk factors, independently worsening patient outcomes.
  • Effective management requires understanding the interplay between diabetes and HFrEF.

Purpose of the Study:

  • To review current evidence on managing type 2 diabetes in stage C HFrEF.
  • To analyze data from major heart failure trials concerning guideline-directed medical therapy in diabetic patients.
  • To preview emerging clinical trials for this patient population.

Main Methods:

  • Literature review of landmark heart failure trials.
  • Analysis of data on guideline-directed medical therapy (GDMT) for HFrEF in patients with diabetes.
  • Synthesis of evidence regarding novel antidiabetic therapies with cardiovascular benefits.

Main Results:

  • Novel antidiabetic agents have demonstrated significant benefits in heart failure outcomes.
  • Guideline-directed medical therapy for HFrEF shows efficacy in patients with diabetes.
  • Understanding the bidirectional impact of diabetes and HFrEF is crucial for treatment.

Conclusions:

  • Clinicians need updated knowledge on managing type 2 diabetes in stage C HFrEF.
  • Emerging therapies offer new avenues for improving outcomes in comorbid patients.
  • Ongoing clinical trials will further refine treatment strategies.

Keywords:
Diabetesantidiabetic agentscardiometabolic risk factorsclinical trialheart failureinsulinsodium–glucose transporter 2 inhibitors

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