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Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis
Dao-Jun Zhang1, Fei Hao1, Tian Qian1
1Department of Dermatology and Plastic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Pediatrics
|April 18, 2022
Summary
This meta-analysis found increased T helper type 22 (Th22) and T helper type 17 (Th17) cells, along with elevated interleukin-17 (IL-17), in atopic dermatitis (AD) patients. Regulatory T cells (Tregs) were decreased, suggesting their role in AD pathogenesis.
Area of Science:
- Immunology
- Dermatology
- Genetics
Background:
- Atopic dermatitis (AD) is a prevalent inflammatory skin condition with a significant incidence in infancy.
- Understanding the immunological underpinnings of AD is crucial for developing targeted therapies.
Approach:
- A meta-analysis was conducted, systematically reviewing eight studies published up to July 2021.
- Data from peripheral blood samples of AD patients and healthy controls were analyzed using Stata software.
Key Points:
- Patients with AD exhibited significantly higher proportions of Th22 cells (WMD = 2.07) and Th17 cells (WMD = 1.04) compared to controls.
- Elevated levels of IL-17 (WMD = 17.56) and reduced levels of Tregs (WMD = -2.49) were observed in AD patients.
- Subgroup analysis indicated that increased Th22 cells and decreased Tregs correlated with higher AD disease severity.
Conclusions:
- The findings suggest that Th22 cells, Th17 cells, IL-17, and Tregs play a role in the pathogenic mechanisms of atopic dermatitis.
- These immune cells and cytokines represent potential therapeutic targets for managing AD.
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