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Practical Considerations for Use of Direct Oral Anticoagulants in Children

Hilary Whitworth1, Leslie Raffini1

  • 1Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Frontiers in Pediatrics
|April 18, 2022
PubMed

Insights

Direct oral anticoagulants (DOACs) offer a new option for pediatric thrombosis management. Pediatricians must consider specific patient factors and limited real-world data when using these agents in children.

Area of Science:

  • Pediatric Hematology
  • Pharmacology
  • Thrombosis Management

Background:

  • Direct oral anticoagulants (DOACs) are emerging as alternatives to traditional anticoagulants for pediatric thrombosis.
  • Recent approvals and ongoing trials are reshaping pediatric anticoagulation practices.

Purpose of the Study:

  • To review pediatric-specific data on DOACs.
  • To highlight practical considerations and future research needs for DOAC use in children and adolescents.

Main Methods:

  • Mini-review of existing pediatric data.
  • Analysis of clinical trial outcomes and real-world evidence.

Main Results:

  • DOACs show promise but require careful consideration of pediatric-specific factors.
  • Limited real-world data exists for children outside clinical trial criteria.

Conclusions:

  • DOACs offer a viable option for pediatric anticoagulation.
  • Further research and real-world data are crucial for optimizing DOAC use in diverse pediatric populations.

Keywords:
VTEanticoagulationdirect oral anticoagulantpediatricthrombosis

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