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ENO1 and Cancer.

Chen Kai Huang1, Ying Sun2, Lei Lv3

  • 1Department of Molecular and Cellular Biology, University of California, Berkeley, 110 Sproul Hall, Berkeley, CA 94720, USA.

Molecular Therapy Oncolytics
|April 18, 2022
PubMed
Summary
This summary is machine-generated.

Alpha-enolase (ENO1) is a key cancer oncoprotein involved in tumor growth, immune evasion, and metastasis. Its overexpression and cell surface presence make ENO1 a promising biomarker and therapeutic target for various cancers.

Keywords:
ENO1cancer biomarkerglycolysishallmarks of canceroncotherapytumorigenesis

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Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Alpha-enolase (ENO1), a glycolytic enzyme, functions as a moonlighting oncoprotein.
  • ENO1 is implicated in seven hallmarks of cancer, including sustained proliferation and immune evasion.
  • Its cell surface presence facilitates invasion and metastasis via angiogenesis.

Purpose of the Study:

  • To review the multifaceted roles of ENO1 in cancer.
  • To examine ENO1's potential as a diagnostic and prognostic biomarker.
  • To discuss ENO1's utility in developing novel cancer immunotherapies.

Main Methods:

  • Literature review of studies on ENO1 and cancer.
  • Analysis of ENO1's glycolytic and non-glycolytic functions.
  • Evaluation of ENO1's expression patterns and clinical significance.

Main Results:

  • ENO1 dysregulates cellular energy metabolism, promotes tumor growth, and inhibits apoptosis.
  • ENO1 acts as a cell surface plasminogen receptor, enhancing invasion and metastasis.
  • Overexpressed ENO1 is found in numerous cancer types, correlating with poor prognosis.

Conclusions:

  • ENO1 is a critical oncoprotein with significant implications in cancer progression.
  • ENO1's overexpression and cell surface localization position it as a valuable cancer biomarker.
  • Targeting ENO1 offers potential for innovative oncotherapeutic and immunotherapeutic strategies.