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Nutrition and Microbiome.

Nathalie M Delzenne1, Julie Rodriguez2

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Summary
This summary is machine-generated.

Targeting gut microbiota with prebiotics shows potential for managing obesity and metabolic diseases. However, human responses vary based on individual gut bacteria, influencing treatment efficacy.

Keywords:
Gut microbiotaMetabolic healthNutritionPrebiotics

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Area of Science:

  • Microbiology
  • Metabolism
  • Human Health

Background:

  • Obesity and metabolic diseases are global health crises requiring novel management strategies.
  • The gut microbiota plays a crucial role in host metabolism and is influenced by diet.
  • Nutritional disorders are linked to alterations in gut microbiota composition and function.

Purpose of the Study:

  • To review human interventions using prebiotic supplementation to target the gut microbiome for metabolic health.
  • To explore the influence of gut microbiota composition on individual responses to dietary interventions.

Main Methods:

  • Review of human studies on prebiotic supplementation and its effects on gut microbiota.
  • Analysis of the relationship between baseline gut microbiota characteristics and metabolic responses to diet and prebiotics.

Main Results:

  • Prebiotic interventions show promise in preclinical models but have variable efficacy in humans.
  • Inter-individual variability in response to dietary interventions is significantly influenced by the gut microbiota.

Conclusions:

  • Targeting the gut microbiota with prebiotics is a promising approach for managing obesity and cardio-metabolic risk.
  • Understanding basal gut microbiota profiles is essential for predicting and optimizing responses to prebiotic and dietary fiber interventions.