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ERG Expression is Helpful in Differentiating T-Lymphoblastic Lymphoma from Thymoma
Wenyong Huang1, Wen Zhang1, Lei Zeng1
1Department of Pathology, 196534The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
International Journal of Surgical Pathology
|April 18, 2022
Summary
ETS-related gene (ERG) is expressed in T-lymphoblastic lymphoma but rarely in thymoma. ERG serves as a valuable diagnostic marker to distinguish T-lymphoblastic lymphoma from nonneoplastic T-precursor cells.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- ETS-related gene (ERG), an ETS-family transcription factor, is typically found in Ewing sarcoma.
- Recent findings indicate ERG expression in lymphoblastic lymphoma.
Purpose of the Study:
- To investigate ERG expression patterns in T-lymphoblastic lymphoma.
- To assess the diagnostic utility of ERG for differentiating T-lymphoblastic lymphoma from nonneoplastic T-precursor cells in thymoma.
Main Methods:
- Immunohistochemistry was employed to evaluate ERG expression.
- Specimens analyzed included 16 T-lymphoblastic lymphoma and 18 thymoma samples.
Main Results:
- ERG was expressed in 63% (10/16) of T-lymphoblastic lymphoma specimens.
- ERG expression was observed in only 6% (1/18) of thymoma specimens.
- ERG demonstrated a positive predictive value of 91% and a negative predictive value of 74% for T-lymphoblastic lymphoma.
Conclusions:
- ERG is a useful marker for diagnosing T-lymphoblastic lymphoma.
- ERG shows promise as a method to differentiate T-lymphoblastic lymphoma from nonneoplastic T-precursor cells in thymoma.
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