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How does a celiac iceberg really float? The relationship between celiac disease and gluten
Xiaoxue Zhu1,2, Xin-Huai Zhao3, Qiang Zhang3
1College of Food Science, Southwest University, Chongqing, China.
Critical Reviews in Food Science and Nutrition
|April 18, 2022
Summary
Celiac disease (CD) is an autoimmune disorder triggered by gluten in susceptible individuals. This review covers gluten
Area of Science:
- Gastroenterology and Immunology
- Food Science and Nutrition
Background:
- Celiac disease (CD) is an autoimmune intestinal disorder.
- It is triggered by gluten in genetically susceptible individuals.
- CD exhibits 'iceberg' characteristics, affecting a broad population.
Approach:
- Comprehensive review of current research on celiac disease and gluten.
- Analysis of gluten peptide structure-function relationships.
- Evaluation of gluten detection methods and processing effects.
Key Points:
- Gluten peptides are central to CD pathogenesis.
- Accurate gluten detection is crucial for diagnosis and management.
- Food processing significantly alters gluten's immunogenicity.
Conclusions:
- Understanding gluten's role in CD is vital.
- Further research is needed to address current limitations in CD diagnosis and treatment.
- This review provides a foundation for future celiac disease research.
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