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Researcher Views on Changes in Personality, Mood, and Behavior in Next-Generation Deep Brain Stimulation.

Peter Zuk1, Clarissa E Sanchez2, Kristin Kostick-Quenet2

  • 1Harvard Medical School.

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|April 18, 2022
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Summary

Researchers developing deep brain stimulation (DBS) and adaptive DBS (aDBS) acknowledge potential personality, mood, and behavior changes. They noted both positive and negative effects, with some causes unrelated to the device itself.

Keywords:
Neuroethicsanger/impulsive behaviordeep brain stimulationmovement disorderspersonality changespsychiatric disorders

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Area of Science:

  • Neuroscience
  • Bioethics
  • Medical Technology

Background:

  • Deep brain stimulation (DBS) and adaptive DBS (aDBS) are advanced neuromodulation technologies.
  • Concerns exist regarding potential impacts of DBS/aDBS on personality, mood, and behavior (PMB).

Purpose of the Study:

  • To explore researchers' perspectives on the ethical and policy implications of DBS/aDBS.
  • To investigate expert opinions on whether DBS/aDBS can induce PMB changes.

Main Methods:

  • Semi-structured interviews were conducted with 23 researchers involved in next-generation DBS system development.
  • Qualitative data analysis explored researchers' views on PMB changes associated with DBS/aDBS.

Main Results:

  • A majority of researchers reported awareness of PMB changes in DBS/aDBS recipients.
  • Researchers presented varied frequency estimates and discussed both negative and positive PMB alterations.
  • Some researchers identified causes of PMB changes beyond the device itself.

Conclusions:

  • Expert consensus suggests DBS/aDBS may influence personality, mood, and behavior.
  • The potential for both beneficial and adverse PMB effects warrants further investigation.
  • Understanding the multifaceted causes of PMB changes is crucial for responsible DBS/aDBS development and application.