Related Experiment Video
Updated: Aug 14, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
The mechanism underlying sudden death from electric shock
Abstract:
Much has been written on the effects of electric shock on the body. However, in those cases in which victims become pulseless and therefore die suddenly, the underlying event has assuredly been ventricular fibrillation. In this condition of the heart, all of the muscle fibers of the ventricles, the main pumping chambers, contract and relax randomly and pump no blood. Simple protracted cardiac arrest, in this circumstance, is most unlikely. It generally is believed that only low-frequency alternating current can induce ventricular fibrillation; this assumption is invalid, because a single pulse of current applied to the body, as well as high-frequency current, can induce ventricular fibrillation. The important variables are the type and magnitude of the current and the manner in which it is applied to the body. To date, the current pathway has received too little attention. This article reviews the various mechanisms by which a single shock or a train of pulses can induce ventricular fibrillation.
Related Concept Videos
Voltage-gated Ion Channels
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Depolarizing Blockers: Mechanism of Action
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...
Electrophysiology of Normal Cardiac Rhythm
Mechanism of Cardiac Arrhythmias
Cardiopulmonary Resuscitation III: AED Use
Cellular Injury IV: Necrosis

