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Lipid alterations induced by nifurtimox in Trypanosoma cruzi
Molecular and Biochemical Parasitology
|December 1, 1986
Abstract:
The influence of growth in the presence of nifurtimox on total lipids of Trypanosoma cruzi epimastigotes was determined. Nifurtimox-treated organisms showed greater amounts of unsaturated fatty acids as compared with control cells. 18:2 was the major component in the total esterified lipid fraction. Similar results were observed on the free fatty acid composition as detected by trimethylsilyl derivatization of the total lipids.