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Updated: Sep 26, 2025

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Ten Hotspot MicroRNAs and Their Potential Targets of Chondrocytes Were Revealed in Osteoarthritis Based on

Wei-Shang Hu1, Qi Zhang1,2, Si-Hui Li1

  • 1Acupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Journal of Healthcare Engineering
|April 19, 2022
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are crucial in osteoarthritis (OA) pathogenesis. Bibliometric analysis identified key miRNAs like miR-140 and miR-146, highlighting their potential as diagnostic biomarkers for OA.

Area of Science:

  • Biomedical Research
  • Molecular Biology
  • Genetics

Background:

  • Osteoarthritis (OA) is a prevalent joint disorder with significant debilitating effects.
  • MicroRNAs (miRNAs) are increasingly recognized for their critical role in OA pathogenesis.
  • miRNAs show promise as novel biomarkers and therapeutic targets for osteoarthritis.

Purpose of the Study:

  • To analyze research trends and the current status of microRNA (miRNA) studies in osteoarthritis (OA).
  • To identify hotspot miRNAs associated with OA using bibliometric analysis.
  • To evaluate the global research landscape concerning miRNAs and OA.

Main Methods:

  • Bibliometric analysis of publications on miRNAs and OA from the Web of Science database (up to October 30, 2021).
  • Utilized CiteSpace and VOSviewer software for data analysis.
  • Assessed publication volume, institutional contributions, country-specific research, author impact, and keyword frequency.

Main Results:

  • A total of 1109 articles were analyzed, with research commencing in 2008 and showing an upward trend.
  • Chinese institutions lead in publication quantity but require advancement in high-impact research.
  • Ten key miRNAs (e.g., miR-140, miR-146, miR-34) and chondrocytes were identified as significant in OA pathogenesis.

Conclusions:

  • Bibliometric analysis reveals significant progress in miRNA research for osteoarthritis.
  • Specific miRNAs, including miR-140 and miR-146, are prominent in OA research.
  • Future research focusing on miRNA-regulated chondrocytes could accelerate the development of diagnostic and therapeutic strategies for OA.

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