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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
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Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic
1Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Biomed Research International
|April 19, 2022
Summary
Traumatic brain injury (TBI) impairs brain connectivity, linking to anxiety and depression. Specific brain region connectivity changes can help diagnose TBI and related mood disorders.
Area of Science:
- Neuroscience
- Neurology
- Brain Imaging
Background:
- Traumatic brain injury (TBI) can lead to significant neurological and psychological deficits.
- Understanding interhemispheric functional coordination is crucial for TBI assessment.
Purpose of the Study:
- To investigate interhemispheric functional coordination after TBI.
- To explore the association between altered brain connectivity and posttraumatic anxiety and depressive symptoms.
Main Methods:
- Employed voxel-mirrored homotopic connectivity (VMHC) to assess functional coordination.
- Utilized voxel-based morphometry (VBM) for grey matter volume and diffusion tensor imaging (DTI) for corpus callosum (CC) integrity.
- Assessed anxiety and depression using the Hospital Anxiety and Depression Scale.
Main Results:
- TBI patients showed decreased VMHC in the bilateral middle temporal gyrus (MTG) and orbital middle frontal gyrus (MFG).
- Reduced functional connectivity (FC) in the orbital MFG correlated with anxiety and depressive symptoms.
- Significant white matter integrity reduction in the CC was observed in TBI patients. VMHC of the orbital MFG effectively distinguished TBI from healthy controls (AUC=0.939).
Conclusions:
- TBI disrupts interhemispheric functional and structural connections.
- These disruptions are linked to posttraumatic mood disorders.
- Findings suggest potential clinical utility as diagnostic indicators for TBI.
