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Updated: Sep 26, 2025
08:29
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
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Emerging mRNA technologies: delivery strategies and biomedical applications
Yufen Xiao1, Zhongmin Tang1, Xiangang Huang1
1Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. wtao@bwh.harvard.edu.
Chemical Society Reviews
|April 19, 2022
Summary
Messenger RNA (mRNA) technology shows great promise beyond COVID-19 vaccines. Advances in chemical delivery systems, including nanoparticles, enable diverse biomedical applications and future clinical translation.
Area of Science:
- Biochemistry
- Materials Science
- Nanotechnology
Background:
- Messenger RNA (mRNA) technology has demonstrated significant success, particularly with COVID-19 vaccines.
- Chemistry is crucial for mRNA modification and developing effective delivery systems.
Purpose of the Study:
- To review advancements in emerging mRNA technologies.
- To discuss the chemical designs and principles behind mRNA delivery.
- To highlight applications and future prospects of mRNA technology.
Main Methods:
- Summary and discussion of progress in mRNA technology.
- Presentation of various nanoparticle-based delivery strategies.
- Highlighting typical mRNA delivery platforms for biomedical applications.
Main Results:
- Various nanoparticle (NP)-based delivery strategies are presented, including protein-mRNA complexes, lipid-based, polymer-based, and hybrid carriers.
- Efficient delivery of mRNA molecules is achievable through these diverse platforms.
- Successful applications in functional protein expression, vaccines, cancer immunotherapy, and genome editing are highlighted.
Conclusions:
- Emerging mRNA technologies offer vast potential for biomedical applications.
- Chemical innovation in delivery systems is key to unlocking mRNA's capabilities.
- Further development is needed for successful clinical translation of mRNA technologies.
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