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A multifunctional hydrogel dressing with antibacterial properties for effective wound healing
Ye Zhang1, Dan Yang1, Wei Guo1,2
1Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, Heilongjiang, China. guowei@hrbnu.edu.cn.
Dalton Transactions (Cambridge, England : 2003)
|April 19, 2022
Summary
A new hydrogel dressing combines silver-doped nickel sulfide with polyacrylamide and chitosan. This multifunctional dressing offers advanced antibacterial wound healing through photothermal therapy and radical production.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing
Background:
- Developing advanced wound dressings is crucial for combating bacterial infections.
- Silver nanoparticles and hydrogels show promise in wound care.
- Novel materials are needed to enhance antibacterial efficacy and promote healing.
Purpose of the Study:
- To develop a multifunctional hydrogel dressing for enhanced antibacterial wound healing.
- To investigate the properties of silver-doped yolk-like nickel sulfide (Ag(8.5%)@NiS2-) within a polyacrylamide (PAM) and chitosan (CS) hydrogel matrix.
- To evaluate the dressing's potential for photothermal therapy and reactive oxygen species generation.
Main Methods:
- Synthesized Ag(8.5%)@NiS2- nanoparticles.
- Fabricated a hydrogel dressing incorporating Ag(8.5%)@NiS2-, PAM, and CS.
- Characterized the material's optical absorption, peroxidase-like activity, and antibacterial properties.
- Assessed the hydrogel's capacity for adsorbing bacteria and inflammatory exudates.
Main Results:
- The Ag(8.5%)@NiS2- component exhibited broad optical absorption (200-2500 nm) suitable for photothermal therapy.
- The material demonstrated peroxidase-like activity, catalyzing hydrogen peroxide to produce bactericidal hydroxyl radicals.
- The PAM/CS hydrogel effectively adsorbed bacteria and inflammatory secretions.
- Silver doping enhanced the antibacterial mechanism by disrupting bacterial components.
Conclusions:
- The developed multifunctional hydrogel dressing (dressing-2:1) shows significant potential for antibacterial wound healing.
- The combination of Ag(8.5%)@NiS2- and PAM/CS hydrogel offers synergistic antibacterial and wound healing properties.
- This novel dressing represents a promising strategy for managing infected wounds.
