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Related Experiment Video

Updated: Sep 26, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons.

Aida Maziar1, Tristian N R H Y Critch1, Sourav Ghosh1

  • 1Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.

Cerebral Cortex (New York, N.Y. : 1991)
|April 19, 2022
PubMed
Summary

L-type calcium channels (LTCCs) show unique aging changes in the piriform cortex and hippocampus. Blocking LTCCs impairs adult learning but rescues cognitive deficits in aged rats.

Keywords:
L-type calcium channelsaginghippocampuspiriform cortex

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Area of Science:

  • Neuroscience
  • Aging Research
  • Cognitive Science

Background:

  • Aging leads to cognitive decline and memory loss.
  • Neuronal excitability and learning impairments are common in aging, particularly in the hippocampus.
  • L-type calcium channels (LTCCs) are implicated in these age-related changes.

Purpose of the Study:

  • Investigate the role of LTCCs in the rat piriform cortex (PC) and hippocampus during aging.
  • Compare LTCC function in the PC and hippocampus in adult and aged rats.
  • Determine the effects of LTCC blockade on learning and memory in different age groups.

Main Methods:

  • Used spatial and olfactory learning tasks in adult (6-9 months) and aged (19-23 months) rats.
  • Administered LTCC blocker nimodipine to assess behavioral changes.
  • Examined neuronal excitability, afterhyperpolarization (AHP), and Cav1.2 subunit expression in hippocampal and PC neurons.

Main Results:

  • Nimodipine impaired spatial recognition in adult rats but rescued spatial learning deficits in aged rats.
  • LTCC blockade impaired odor-associative learning in adult rats but rescued it in aged rats.
  • Aged CA1 neurons showed increased AHP and reduced excitability, while aged PC neurons exhibited higher excitability with altered Cav1.2 distribution.

Conclusions:

  • LTCCs play distinct roles in learning and memory across different brain regions and aging.
  • Aging induces unique alterations in LTCCs and neuronal function in the piriform cortex compared to the hippocampus.
  • Targeting LTCCs may offer therapeutic potential for age-related cognitive impairments.