Therapeutic uses of gonadotropin-releasing hormone analogs

|January 1, 1987

Abstract:

Since the discovery and synthesis of gonadotropin-releasing hormone (GnRH) in 1971, numerous long-acting agonistic and antagonistic analogs have been synthesized. Agonistic analogs were found to desensitize pituitary GnRH receptors with chronic use, resulting in decreased gonadotropin secretion and a hypogonadal state. These analogs are being investigated as potential contraceptives and in the treatment of several conditions in which decreased gonadal steroid production is desired. Substantial progress has been made in these areas. The purpose of this review is to provide the clinician with data regarding the potential clinical utility of this class of peptides.

Keywords:

Androgens Animals, Laboratory Behavior Biology Cancer--men Clinical Research Contraception Contraceptive Agents Contraceptive Agents, Female Contraceptive Agents, Male Contraceptive Mode Of Action Dermatological Effects Diseases Economic Factors Endocrine System Endometrial Effects Endometritis Endometrium Family Planning Follicle Stimulating Hormone Genital Effects, Female Genitalia Genitalia, Female Gonadotropins Gonadotropins, Pituitary Hair Diseases Hirsutism Hormones In Vitro Infections Literature Review Luteinizing Hormone Menstruation Disorders Neoplasms Ovulation Ovulation Suppression Physiology Pituitary Hormone Releasing Hormones--side effects Psychological Factors Reproduction Reproductive Control Agents Reproductive Tract Infections Research And Development Research Methodology Sex Behavior Signs And Symptoms Technology Treatment Urogenital Effects Urogenital System Uterine Effects Uterus

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