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COVID-19 death and kidney disease in a multiracial Asian country

Bak Leong Goh1,2, Malini Shanmuganathan1, Kalaiarasu Peariasamy3

  • 1Clinical Research Centre, Hospital Serdang, Kajang, Selangor, Malaysia.

Nephrology (Carlton, Vic.)
|April 19, 2022
PubMed

Insights

Predictors of death in COVID-19 patients include older age, Chinese ethnicity, diabetes, and kidney disease. Hospital resources also impact mortality, highlighting disparities in care.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 infection poses significant mortality risks, particularly for patients with kidney disease (KD).
  • Identifying predictors of mortality and KD is crucial for improving patient outcomes and management strategies.

Purpose of the Study:

  • To identify predictors of death and acute kidney injury (AKI) in hospitalized COVID-19 patients.
  • To analyze the influence of patient demographics, comorbidities, and healthcare center capacity on mortality and AKI.

Main Methods:

  • Prospective, multicentre observational study.
  • Inclusion of 6078 hospitalized COVID-19 patients from January to June 2020 in a multiracial Asian country.
  • Statistical analysis to identify significant predictors of death and AKI after covariate adjustment.

Main Results:

  • Overall case fatality rate (CFR) was 1.3%; however, patients with KD had a CFR of 20%.
  • Significant predictors of death included advanced age (>70 years), Chinese ethnicity, diabetes mellitus (DM), and KD.
  • Adjusted predictors for AKI were age (>51 years), DM, and disease severity at presentation. Chinese ethnicity was associated with a 2.58-fold increased risk of death compared to Malay.
  • Center capacity for management, ventilation, and dialysis significantly influenced patient mortality.

Conclusions:

  • Both patient-specific factors and healthcare center capacity are significant determinants of death and AKI in COVID-19 patients.
  • The study highlights racial disparities in mortality rates and variations in outcomes based on healthcare resource availability within a multiracial Asian setting.
Abstract

Keywords:
COVID-19deathethnicitykidney diseaserisk factors

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